Villin 2 (ezrin)
PDB rendering based on 1ni2.
Available structures: 1ni2
Identifiers
Symbols	VIL2; CVIL; CVL; DKFZp762H157; FLJ26216; MGC1584
External IDs	OMIM: 123900 MGI: 98931 HomoloGene: 55740
Gene ontology Molecular function: • structural molecule activity • cytoskeletal protein binding • protein self-association • actin filament binding Cellular component: • ruffle • cytoplasm • cytosol • cytoskeleton • actin filament • microvillus • membrane • extrinsic to membrane • cortical cytoskeleton Biological process: • cytoskeletal anchoring • regulation of cell shape • actin filament bundle formation
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	7430	22350
Ensembl	ENSG00000092820	ENSMUSG00000052397
Uniprot	P15311	Q3TCP5
Refseq	NM_003379 (mRNA) NP_003370 (protein)	NM_009510 (mRNA) NP_033536 (protein)
Location	Chr 6: 159.11 - 159.16 Mb	Chr 17: 6.59 - 6.63 Mb
Pubmed search	[1]	[2]

Villin 2 (ezrin), also known as VIL2, is a human gene.

The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. It plays a key role in cell surface structure adhesion, migration, and organization.¹

References

Further reading

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