Tiletamine 

Tiletamine
Systematic (IUPAC) name
2-ethylamino-2-(2-thienyl) cyclohexanone
Identifiers
CAS number  ?
ATC code  ?
PubChem  ?
Chemical data
Formula C12H17NOS 
Mol. mass 223.34 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism Liver
Half life  ?
Excretion Kidneys
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes  ?

Tiletamine is a dissociative anesthetic and pharmacologically classified as an NMDA receptor antagonist. It is related chemically and pharmacologically to other anesthetics in this family such as ketamine and phencyclidine. Tiletamine hydrochloride exists as odourless white crystals.

It is used in veterinary medicine in the compound product Telazol (tiletamine/zolazepam, 50mg/ml of each in 5ml vial) as an injectable anesthetic. It is sometimes used in combination with xylazine (Rompun) to tranquilize large mammals such as bears and horses. Telazol is the only commercially available tiletamine product in the USA.

It is contraindicated in patients of an ASA statues of III or greater and in animals with CNS signs, hyperthyroidism, cardiac disease, pancreatic or renal disease, pregnancy, glaucoma, or penetrating eye injuries.

Tiletamine/zolazepam products are classified as Schedule III controlled substances in the United States.

References

 This article does not cite any references or sources.
Please help improve this article by adding citations to reliable sources. Unverifiable material may be challenged and removed. (October 2008)
v • d • e
Dissociative hallucinogens
Kappa agonists
NMDA receptor antagonists
Others
v • d • e
Glutamate receptor ligands
Ionotropic
Agonists; NMDA • Tetrazolylglycine
Antagonists; Competitive antagonists; AP7 • AP5 • CGP-37849 • Midafotel (CPPene) • PEAQX • Perzinfotel • PPDA • Sdz 220-581 • Selfotel; Noncompetitive antagonists; Aptiganel • Dizocilpine • FPL-12495 • FR-115,427 • Gacyclidine • Hodgkinsine • HU-211 • Indantadol • Psychotridine • Remacemide; Uncompetitive channel blockers; 2-MDP • 8a-Phenyldecahydroquinoline • Amantadine • Budipine • Delucemine • Dexoxadrol • Dextromethorphan • Dextrorphan • Endopsychosin • Etoxadrol • Eticyclidine • Ibogaine • Ketamine • Memantine • NEFA • Neramexane • Nitrous oxide • Phencyclidine • Rhynchophylline • Riluzole • Rolicyclidine • Tenocyclidine • Tiletamine • Xenon; Glycine site antagonists; 1-Aminocyclopropanecarboxylic acid • ACEA-1021 • 7-Chlorokynurenate • CGP-39653 • DCKA • Gavestinel • GV-150,526 • Kynurenic acid • L-689,560 • Lacosamide • ZD-9379; Polyamine site antagonists; Besonprodil • CP-101,606 • Eliprodil • Ifenprodil • Ro25-6981 • Traxoprodil; Indirect antagonists; Lubeluzole
Agonists; AMPA • Domoic acid • 5-Fluorowillardiine; Positive allosteric modulators; Aniracetam • Cyclothiazide • CX-516 • CX-546 • CX-614 • CX-691 • CX-717 • IDRA-21 • LY-392,098 • LY-404,187 • LY-451,395 • LY-451,646 • LY-503,430 • Oxiracetam • PEPA • Piracetam • Pramiracetam
Antagonists; ATPO • CNQX • DNQX • NBQX • Tezampanel (LY-293,558); Negative allosteric modulators; GYKI-53,655
Agonists; 5-Iodowillardiine • ATPA • Domoic acid • Kainic acid • LY-339,434 • SYM-2081
Antagonists; CNQX • DNQX • LY-382,884 • NBQX • NS102 • UBP-302; Negative allosteric modulators; NS-3763
Metabotropic
Agonists; Unselective; ACPD • Dihydroxyphenylglycine; mGlu1 selective; Ro01-6128; mGlu5 selective; CHPG • DFB
Antagonists; Unselective; MCPG; mGlu1 selective; BAY 36-7620 • CPCCOEt • LY-367,385; mGlu5 selective; LY-344,545 • MPEP • MTEP
Agonists; Unselective; Eglumegad (LY-354,740) • LY-404,039; mGlu2 selective; BINA • LY-487,379
Antagonists; EGLU • LY-341,495
Agonists; Unselective; AP4; mGlu4 selective; PHCCC; mGlu8 selective; DCPG
Antagonists; CPPG • UBP-1112
Tablets  This pharmacology-related article is a stub. You can help Wikipedia by expanding it.