Pythia can mean:

• Pythia, an ancient Greek priestess at the Oracle of Apollo at Delphi
• Pythia, a symphonic metal band from the UK
• 432 Pythia, a main belt asteroid named after the ancient Greek priestess
• PYTHIA, a particle physics event generator
• Pythia (Battlestar Galactica), a fictional character from the new Battlestar Galactica, who is an Oracle, and writer of religious texts
• The Axis of Pythia, a fictional item used in an episode of Angel which creates a gateway to the Higher Powers
• Pythia of Gallifrey, a fictional character from the British TV series Doctor Who who once ruled Gallifrey

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