Nabumetone 

Nabumetone
Systematic (IUPAC) name
4-(6-methoxy-2-naphthyl)-2-butanone
Identifiers
CAS number 42924-53-8
ATC code M01AX01
PubChem 4409
DrugBank APRD01128
Chemical data
Formula C15H16O2 
Mol. mass 228.29 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding > 99% (active metabolite)
Metabolism Hepatic, to active metabolite 6-methoxy-2-naphthylacetic acid
Half life 23 hours (active metabolite)
Excretion Renal
Therapeutic considerations
Pregnancy cat.

?
Legal status

POM
Routes Oral

Nabumetone is a non-steroidal anti-inflammatory drug1 of the arylalkanoic acid family (which includes diclofenac). It is available under numerous brand names, such as Relafen, Relifex and Gambaran.

It is used to treat pain or inflammation caused by arthritis. Nabumetone works by reducing the effects of hormones that cause pain and inflammation.

It has been shown to have a slightly lower risk of gastrointestinal side effects than most other non-selective NSAID's.

References

  1. ^ Gonzalo-Garijo MA, Cordobés-Duran C, Lamilla-Yerga AM, Moreno-Gastón I (2007). "Severe immediate reaction to nabumetone". Journal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología 17 (4): 274–6. PMID 17694703. 
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Anti-inflammatory products (M01A)
Pyrazolidine/Butylpyrazolidines
Acetic acid derivatives
and related substances
Oxicams
Propionic acid derivatives
Fenamates
Coxibs
Other
v • d • e
Non-steroidal anti-inflammatory drug (NSAID) products (primarily M01A and M02A, also N02BA)
Salicylates
Arylalkanoic acids
2-Arylpropionic acids
(profens)
N-Arylanthranilic acids
(fenamic acids)
Pyrazolidine derivatives
Oxicams
COX-2 inhibitors
Sulphonanilides
Topically used products
COX-inhibiting nitric oxide donators
Others
Items listed in bold indicate initially developed compounds of specific groups. †Withdrawn drugs. ‡Veterinary use medications.