NFE2

Gene ontology

Molecular function:

• transcription factor activity
• transcription coactivator activity
• sequence-specific DNA binding
• protein dimerization activity

Cellular component:

• nucleus

Biological process:

• transcription
• regulation of transcription from RNA polymerase II promoter
• multicellular organismal development
• hemostasis
• circulation

Nuclear factor (erythroid-derived 2), 45kDa, also known as NFE2, is a human gene.¹

Further reading

Strauss EC, Andrews NC, Higgs DR, Orkin SH (1992). "In vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reaction.". Mol. Cell. Biol. 12 (5): 2135–42. PMID 1569944.
Pischedda C, Cocco S, Melis A, et al. (1995). "Isolation of a differentially regulated splicing isoform of human NF-E2.". Proc. Natl. Acad. Sci. U.S.A. 92 (8): 3511–5. PMID 7724591.
Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, et al. (1995). "Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development.". Cell 81 (5): 695–704. PMID 7774011.
Igarashi K, Kataoka K, Itoh K, et al. (1994). "Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins.". Nature 367 (6463): 568–72. doi:10.1038/367568a0. PMID 8107826.
Chan JY, Han XL, Kan YW (1994). "Isolation of cDNA encoding the human NF-E2 protein.". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11366–70. PMID 8248255.
Ney PA, Andrews NC, Jane SM, et al. (1993). "Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner.". Mol. Cell. Biol. 13 (9): 5604–12. PMID 8355703.
Toki T, Itoh J, Kitazawa J, et al. (1997). "Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif.". Oncogene 14 (16): 1901–10. doi:10.1038/sj.onc.1201024. PMID 9150357.
Blank V, Kim MJ, Andrews NC (1997). "Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression.". Blood 89 (11): 3925–35. PMID 9166829.
Gavva NR, Gavva R, Ermekova K, et al. (1997). "Interaction of WW domains with hematopoietic transcription factor p45/NF-E2 and RNA polymerase II.". J. Biol. Chem. 272 (39): 24105–8. PMID 9305852.
Mosser EA, Kasanov JD, Forsberg EC, et al. (1998). "Physical and functional interactions between the transactivation domain of the hematopoietic transcription factor NF-E2 and WW domains.". Biochemistry 37 (39): 13686–95. doi:10.1021/bi981310l. PMID 9753456.
Hung HL, Kim AY, Hong W, et al. (2001). "Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation.". J. Biol. Chem. 276 (14): 10715–21. doi:10.1074/jbc.M007846200. PMID 11154691.
Gavva NR, Wen SC, Daftari P, et al. (2002). "NAPP2, a peroxisomal membrane protein, is also a transcriptional corepressor.". Genomics 79 (3): 423–31. doi:10.1006/geno.2002.6714. PMID 11863372.
Boulanger L, Sabatino DE, Wong EY, et al. (2003). "Erythroid expression of the human alpha-spectrin gene promoter is mediated by GATA-1- and NF-E2-binding proteins.". J. Biol. Chem. 277 (44): 41563–70. doi:10.1074/jbc.M208184200. PMID 12196550.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Marini MG, Asunis I, Chan K, et al. (2003). "Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation.". Blood Cells Mol. Dis. 29 (2): 145–58. PMID 12490281.
Onishi Y, Kiyama R (2003). "Interaction of NF-E2 in the human beta-globin locus control region before chromatin remodeling.". J. Biol. Chem. 278 (10): 8163–71. doi:10.1074/jbc.M209612200. PMID 12509425.
Newman JR, Keating AE (2003). "Comprehensive identification of human bZIP interactions with coiled-coil arrays.". Science 300 (5628): 2097–101. doi:10.1126/science.1084648. PMID 12805554.
Chuen CK, Li K, Yang M, et al. (2004). "Interleukin-1beta up-regulates the expression of thrombopoietin and transcription factors c-Jun, c-Fos, GATA-1, and NF-E2 in megakaryocytic cells.". J. Lab. Clin. Med. 143 (2): 75–88. doi:10.1016/j.lab.2003.09.006. PMID 14966463.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

External links

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References

Further reading

External links