N-cadherin

N-cadherin

Cadherin 2, type 1, N-cadherin (neuronal)

PDB rendering based on 1ncg.

Available structures: 1ncg, 1nch, 1nci, 1ncj

Identifiers

Symbols CDH2; CDHN; CDw325; NCAD

External IDs OMIM: 114020 MGI: 88355 HomoloGene: 20424

Gene ontology

Molecular function: • calcium ion binding
• protein binding

Cellular component: • adherens junction
• membrane
• integral to membrane
• lamellipodium
• synapse

Biological process: • cell adhesion
• homophilic cell adhesion
• calcium-dependent cell-cell adhesion
• cell migration
• blood vessel morphogenesis

RNA expression pattern

More reference expression data

Orthologs

Human Mouse

Entrez 1000 12558

Ensembl ENSG00000170558 ENSMUSG00000024304

Uniprot P19022 Q3UIC2

Refseq NM_001792 (mRNA)
NP_001783 (protein) XM_983109 (mRNA)
XP_988203 (protein)

Location Chr 18: 23.78 - 24.01 Mb Chr 18: 16.73 - 16.95 Mb

Pubmed search [1] [2]

Cadherin 2, type 1, N-cadherin (neuronal), also known as CDH2, is a human gene. CDH2 has also been designated as CD325 (cluster of differentiation 325).

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprising five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.¹

References

^ "Entrez Gene: CDH2 cadherin 2, type 1, N-cadherin (neuronal)".

Further reading

Doherty P, Smith P, Walsh FS (1997). "Shared cell adhesion molecule (CAM) homology domains point to CAMs signalling via FGF receptors.". Perspectives on developmental neurobiology 4 (2-3): 157–68. PMID 9168198.
Makrigiannakis A, Coukos G, Blaschuk O, Coutifaris C (2000). "Follicular atresia and luteolysis. Evidence of a role for N-cadherin.". Ann. N. Y. Acad. Sci. 900: 46–55. PMID 10818391.
Hazan RB, Qiao R, Keren R, et al. (2004). "Cadherin switch in tumor progression.". Ann. N. Y. Acad. Sci. 1014: 155–63. PMID 15153430.
Cavallaro U (2005). "N-cadherin as an invasion promoter: a novel target for antitumor therapy?". Current opinion in investigational drugs (London, England : 2000) 5 (12): 1274–8. PMID 15648948.
Salomon D, Ayalon O, Patel-King R, et al. (1992). "Extrajunctional distribution of N-cadherin in cultured human endothelial cells.". J. Cell. Sci. 102 ( Pt 1): 7–17. PMID 1500442.
Knudsen KA, Wheelock MJ (1992). "Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin.". J. Cell Biol. 118 (3): 671–9. PMID 1639850.
Reid RA, Hemperly JJ (1990). "Human N-cadherin: nucleotide and deduced amino acid sequence.". Nucleic Acids Res. 18 (19): 5896. PMID 2216790.
Walsh FS, Barton CH, Putt W, et al. (1990). "N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene.". J. Neurochem. 55 (3): 805–12. PMID 2384753.
Selig S, Bruno S, Scharf JM, et al. (1995). "Expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene.". Proc. Natl. Acad. Sci. U.S.A. 92 (9): 3702–6. PMID 7731968.
Wallis J, Fox MF, Walsh FS (1994). "Structure of the human N-cadherin gene: YAC analysis and fine chromosomal mapping to 18q11.2.". Genomics 22 (1): 172–9. doi:10.1006/geno.1994.1358. PMID 7959764.
Andersson AM, Edvardsen K, Skakkebaek NE (1995). "Expression and localization of N- and E-cadherin in the human testis and epididymis.". Int. J. Androl. 17 (4): 174–80. PMID 7995652.
Matsuyoshi N, Imamura S (1997). "Multiple cadherins are expressed in human fibroblasts.". Biochem. Biophys. Res. Commun. 235 (2): 355–8. doi:10.1006/bbrc.1997.6707. PMID 9199196.
Navarro P, Ruco L, Dejana E (1998). "Differential localization of VE- and N-cadherins in human endothelial cells: VE-cadherin competes with N-cadherin for junctional localization.". J. Cell Biol. 140 (6): 1475–84. PMID 9508779.
Gaidar YA, Lepekhin EA, Sheichetova GA, Witt M (1998). "Distribution of N-cadherin and NCAM in neurons and endocrine cells of the human embryonic and fetal gastroenteropancreatic system.". Acta Histochem. 100 (1): 83–97. PMID 9542583.
Kremmidiotis G, Baker E, Crawford J, et al. (1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity.". Genomics 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.
Lu Q, Paredes M, Medina M, et al. (1999). "delta-catenin, an adhesive junction-associated protein which promotes cell scattering.". J. Cell Biol. 144 (3): 519–32. PMID 9971746.
Shan WS, Tanaka H, Phillips GR, et al. (2000). "Functional cis-heterodimers of N- and R-cadherins.". J. Cell Biol. 148 (3): 579–90. PMID 10662782.
Husi H, Ward MA, Choudhary JS, et al. (2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.". Nat. Neurosci. 3 (7): 661–9. doi:10.1038/76615. PMID 10862698.

External links

MeSH CDH2+protein,+human

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 (a-c, 1A, 1D, 1E) - CD2 - CD3 (γ, δ, ε) - CD4 - CD5 - CD6 - CD7 - CD8 (a) - CD9 - CD10 - CD11 (a, b, c) - CD13 - CD14 - CD15 - CD16 (A, B) - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 (A, B) - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 (a, b, c, d) - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 (a, b, c, d, e, f) - CD50

51-100	CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 (E, L, P) - CD63 - CD64 - CD66 (a, b, c, d, e, f) - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD78 - CD79 (a, b) - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 (a, d, e, h, j, k) - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100

101-150	CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 (a, b) - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 (a, b) - CD121 (a, b) - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150

151-200	CD151 - CD152 - CD153 - CD154 - CD155 - CD156 (a, b, c) - CD157 - CD158 (a, d, e, i, k) - CD159 (a, c) - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 (a, b) - CD168 - CD169 - CD170 - CD171 - CD172 (a, b, g) - CD174 - CD177 - CD178 - CD179 (a, b) - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200

201-250	CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 (a, b) - CD212 - CD213a (1, 2) - CD217 - CD218 (a, b) - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 (a, b) - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249

251-300	CD252 - CD253 - CD254 - CD256 - CD257 - CD258 - CD261 - CD262 - CD264 - CD265 - CD266 - CD267 - CD268 - CD269 - CD271 - CD272 - CD273 - CD274 - CD275 - CD276 - CD278 - CD279 - CD280 - CD281 - CD282 - CD283 - CD284 - CD286 - CD288 - CD289 - CD290 - CD292 - CDw293 - CD294 - CD295 - CD297 - CD298 - CD299

301-350	CD300A - CD304 - CD305 - CD307 - CD309 - CD312 - CD314 - CD315 - CD316 - CD317 - CD318 - CD320 - CD321 - CD322 - CD324 - CD325 - CD326 - CD328 - CD329 - CD331 - CD332 - CD333 - CD334 - CD335 - CD336 - CD337 - CD338 - CD339 - CD340 - CD344 - CD349 - CD350

v • d • e Membrane proteins: cell adhesion molecules

IgSF	N-CAM (Myelin protein zero) - ICAM (1, 4) - VCAM-1 - PE-CAM - L1-CAM

Cadherins	Desmoglein (DSG1, DSG2, DSG3, DSG4) - Desmocollin (DSC1, DSC2, DSC3) - T-cadherin - Protocadherin - CDH1 - CDH2 - CDH3 - CDH4 - CDH5 - CDH6 - CDH8 - CDH11 - CDH12 - CDH15 - CDH16 - CDH17

Selectins	E-selectin - L-selectin - P-selectin

Integrins	LFA-1 - Integrin alphaXbeta2 - Macrophage-1 antigen - VLA-4 - Glycoprotein IIb/IIIa (Note: integrins not always classified as CAMs)

Other	Carcinoembryonic antigen - CD22 - CD24 - CD44 - CD146 - CD164