Methoxy arachidonyl fluorophosphonate
IUPAC name	methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14- tetraenylphosphonofluoridate
Other names	MAFP
Properties
Molecular formula	C21H36FO2P
Molar mass	370.5
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references

Methoxy arachidonyl fluorophosphonate, commonly referred as MAFP, is an irreversible active site-directed enzyme inhibitor that inhibits nearly all serine hydrolases and serine proteases ¹. It inhibits phospholipase A2 and fatty acid amide hydrolase with special potency, displaying IC₅₀ values in the low-nanomolar range.

See also

• DIFP - diisopropyl fluorophosphate, a related inhibitor
• Activity based probes

References

1. ^ Hoover HS, Blankman JL, Niessen S, Cravatt BF (July 2008). "Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling". Bioorg. Med. Chem. Lett.. doi:10.1016/j.bmcl.2008.06.091. PMID 18657971. 

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