MAFB_(gene)

Gene ontology

Molecular function:

• transcription factor activity
• transcription factor binding
• sequence-specific DNA binding
• protein dimerization activity

Cellular component:

• nucleus
• transcription factor complex

Biological process:

• transcription
• segment specification
• sensory organ development
• respiratory gaseous exchange
• inner ear morphogenesis
• negative regulation of erythrocyte differentiation
• positive regulation of transcription from RNA polymerase II promoter

V-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian), also known as MAFB, is a human gene.¹

The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns.¹

References

^ ^a ^b "Entrez Gene: MAFB v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)".

Further reading

Cordes SP, Barsh GS (1995). "The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor.". Cell 79 (6): 1025–34. PMID 8001130.
Sieweke MH, Tekotte H, Frampton J, Graf T (1996). "MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation.". Cell 85 (1): 49–60. PMID 8620536.
Stoffel M, Le Beau MM, Espinosa R, et al. (1996). "A yeast artificial chromosome-based map of the region of chromosome 20 containing the diabetes-susceptibility gene, MODY1, and a myeloid leukemia related gene.". Proc. Natl. Acad. Sci. U.S.A. 93 (9): 3937–41. PMID 8632993.
Wang PW, Eisenbart JD, Cordes SP, et al. (1999). "Human KRML (MAFB): cDNA cloning, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias.". Genomics 59 (3): 275–81. doi:10.1006/geno.1999.5884. PMID 10444328.
Li R, Pei H, Watson DK, Papas TS (2000). "EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes.". Oncogene 19 (6): 745–53. doi:10.1038/sj.onc.1203385. PMID 10698492.
Yamada K, Tomita H, Yoshiura K, et al. (2000). "An autosomal dominant posterior polar cataract locus maps to human chromosome 20p12-q12.". Eur. J. Hum. Genet. 8 (7): 535–9. doi:10.1038/sj.ejhg.5200485. PMID 10909854.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Rosenberger G, Jantke I, Gal A, Kutsche K (2003). "Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling.". Hum. Mol. Genet. 12 (2): 155–67. PMID 12499396.
Hashizume H, Hamalainen H, Sun Q, et al. (2004). "Downregulation of mafB expression in T-helper cells during early differentiation in vitro.". Scand. J. Immunol. 57 (1): 28–34. PMID 12542795.
Fernández-Calotti PX, Salamone G, Gamberale R, et al. (2004). "Downregulation of mac-1 expression in monocytes by surface-bound IgG.". Scand. J. Immunol. 57 (1): 35–44. PMID 12542796.
Mechta-Grigoriou F, Giudicelli F, Pujades C, et al. (2003). "c-jun regulation and function in the developing hindbrain.". Dev. Biol. 258 (2): 419–31. PMID 12798298.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kim JC, Badano JL, Sibold S, et al. (2004). "The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression.". Nat. Genet. 36 (5): 462–70. doi:10.1038/ng1352. PMID 15107855.
Sevinsky JR, Whalen AM, Ahn NG (2004). "Extracellular signal-regulated kinase induces the megakaryocyte GPIIb/CD41 gene through MafB/Kreisler.". Mol. Cell. Biol. 24 (10): 4534–45. PMID 15121870.
Petersen HH, Hilpert J, Jacobsen C, et al. (2004). "Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development.". FEBS Lett. 565 (1-3): 23–7. doi:10.1016/j.febslet.2004.03.069. PMID 15135046.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Bakri Y, Sarrazin S, Mayer UP, et al. (2005). "Balance of MafB and PU.1 specifies alternative macrophage or dendritic cell fate.". Blood 105 (7): 2707–16. doi:10.1182/blood-2004-04-1448. PMID 15598817.
Gemelli C, Montanari M, Tenedini E, et al. (2006). "Virally mediated MafB transduction induces the monocyte commitment of human CD34+ hematopoietic stem/progenitor cells.". Cell Death Differ. 13 (10): 1686–96. doi:10.1038/sj.cdd.4401860. PMID 16456583.
Lee LC, Zhang AY, Chong AK, et al. (2006). "Expression of a novel gene, MafB, in Dupuytren's disease.". The Journal of hand surgery 31 (2): 211–8. doi:10.1016/j.jhsa.2005.09.007. PMID 16473681.

External links

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