Lucey-Driscoll

Lucey-Driscoll syndrome

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Lucey-Driscoll syndrome
Classification and external resources

ICD-9 774.30

OMIM 237900

DiseasesDB 32677

Lucey-Driscoll syndrome Classification and external resources
ICD-9	774.30
OMIM	237900
DiseasesDB	32677

Lucey-Driscoll syndrome is an autosomal recessive metabolic disorder affecting enzymes involved in bilirubin metabolism.

It is one of several disorders classified as a transient familial neonatal unconjugated hyperbilirubinemia.

Cause

The common cause is congenital, but it can also be caused by maternal steroids passed on through breast milk to the newborn. It is different from breast milk jaundice (breast-fed infants have higher bilirubin levels than formula-fed ones).

Genetics

Lucey-Driscoll syndrome has an autosomal recessive pattern of inheritance.

A defect in the UGT1A1-gene, also linked to Crigler-Najjar syndrome and Gilbert's syndrome, is responsible for the congenital form of Lucey-Driscoll syndrome.

External links

Online 'Mendelian Inheritance in Man' (OMIM) 237900 - transient familial neonatal hyperbilirubinemia, breast feeding jaundice included
Hyperbilirubinemia, Unconjugated at eMedicine
Lucey Driscoll syndrome at NIH's Office of Rare Diseases

v • d • e Heme metabolism disorders (E80, 277.1, 277.4)

Porphyrin	Hepatic porphyria: Acute intermittent - Cutanea tarda/Hepatoerythropoietic - Hereditary copro- - Variegate Erythropoietic: Gunther

Hereditary hyperbilirubinemia	Unconjugated: Lucey-Driscoll syndrome - Gilbert's syndrome - Crigler-Najjar syndrome Conjugated: Dubin-Johnson syndrome - Rotor syndrome

see also porphyrin metabolism enzymes, intermediates

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