Keratin

Keratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.¹

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Ku NO, Omary MB (1994). "Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization". J. Cell Biol. 127 (1): 161–71. doi:10.1083/jcb.127.1.161. PMID 7523419.
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Yoon SJ, LeBlanc-Straceski J, Ward D, et al. (1995). "Organization of the human keratin type II gene cluster at 12q13". Genomics 24 (3): 502–8. doi:10.1006/geno.1994.1659. PMID 7536183.
Ku NO, Omary MB (1995). "Identification and mutational analysis of the glycosylation sites of human keratin 18". J. Biol. Chem. 270 (20): 11820–7. PMID 7538124.
Neumaier M, Gerhard M, Wagener C (1995). "Diagnosis of micrometastases by the amplification of tissue-specific genes". Gene 159 (1): 43–7. doi:10.1016/0378-1119(94)00522-T. PMID 7541767.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. PMID 8125298.
Liao J, Lowthert LA, Ku NO, et al. (1996). "Dynamics of human keratin 18 phosphorylation: polarized distribution of phosphorylated keratins in simple epithelial tissues". J. Cell Biol. 131 (5): 1291–301. PMID 8522590.
Ku NO, Wright TL, Terrault NA, et al. (1997). "Mutation of human keratin 18 in association with cryptogenic cirrhosis". J. Clin. Invest. 99 (1): 19–23. doi:10.1172/JCI119127. PMID 9011570.
Ji H, Reid GE, Moritz RL, et al. (1997). "A two-dimensional gel database of human colon carcinoma proteins". Electrophoresis 18 (3-4): 605–13. doi:10.1002/elps.1150180344. PMID 9150948.

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Further reading