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Homophilic binding is a common name for process that is involved in cell adhesion, also called cell-junction. Homophilic binding is a binding between two identical components of the cell junction. In the cell we have cadherins that are Ca²⁺ dependent like:

• tight junction
• adherence junction
• desmosome junction

The Homophilic binding is different from heterophilic binding in that the latter is a binding between 2 non-identical components of each cell, like Selectin or integrins.

Examples of Cell adhesion molecules involved in homophilic interactions include cadherins and members of the Ig-superfamily.

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