Fight or Flight may refer to:

• Fight-or-flight response, the biological response of animals to acute stress
• Fight or Flight, an album by the British rock band Turin Brakes
• "Fight or Flight", a first season episode of Star Trek: Enterprise
• "Fight or Flight", an episode of the science fiction television series Heroes
• "Fight or Flight", an episode of the USA Network television show Burn Notice
• Fight or Flight (documentary)

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