Brain may refer to:
- brain, an organ part of many vertebrates' nervous systems
- Brain, Côte-d'Or, the name of a commune in the Côte-d'Or département in France
- Brain, (real name Bryan Mantia) a drummer who has played with several bands including Primus and Praxis
- Brain, titular character in the cartoon Pinky and the Brain
- Brain (Inspector Gadget), the name of the dog in the cartoon Inspector Gadget
- Brain is also an often misspelled typo of the name Brian.
- C.K. "Bob" Brain, paleontologist.
- Russell Brain, a neurologist
- Dennis Brain, A British Horn player.
- Aubrey Brain, Dennis Brain's father, also a Horn player.
- "The Brain", nickname of Bobby Heenan, wrestler and manager
- Brain (journal), a neurological medical journal
- Brain Records, a German krautrock record label from the 70s
- (c)Brain, a computer virus
- Brains Brewery, a brewery in Wales
- Brain, a slang term for fellatio
- Brain (comics), a DC Comics villain
- Brain (novel), by Robin Cook
- Observer (MST3K), often called "Brain Guy"
- "Brain," a song by N*E*R*D from their 2001 album In Search of...
- As a verb, to inflict blunt force trauma to someone's head.
- "The Brain", English title for movie "Le Cerveau" starring David Niven
- Brain, The (comics), a Bell Features hero
- Marshall Brain
- Brain- Nickname for popular Arthur character.
The adjective cerebral, usually meaning pertaining to the brain, can have special meanings:
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