Apoptosis_antagonizing_transcription

Gene ontology

Molecular function:

• transcription factor activity
• protein binding

Cellular component:

Biological process:

Apoptosis antagonizing transcription factor, also known as AATF, is a human gene.¹

The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.¹

References

^ ^a ^b "Entrez Gene: AATF apoptosis antagonizing transcription factor".

Further reading

Page G, Lödige I, Kögel D, Scheidtmann KH (2000). "AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis.". FEBS Lett. 462 (1-2): 187–91. PMID 10580117.
Fanciulli M, Bruno T, Di Padova M, et al. (2000). "Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb.". FASEB J. 14 (7): 904–12. PMID 10783144.
Lindfors K, Halttunen T, Huotari P, et al. (2000). "Identification of novel transcription factor-like gene from human intestinal cells.". Biochem. Biophys. Res. Commun. 276 (2): 660–6. doi:10.1006/bbrc.2000.3480. PMID 11027528.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. PMID 11790298.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus.". Mol. Biol. Cell 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMID 12429849.
Bruno T, De Angelis R, De Nicola F, et al. (2003). "Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb.". Cancer Cell 2 (5): 387–99. PMID 12450794.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Di Padova M, Bruno T, De Nicola F, et al. (2003). "Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter.". J. Biol. Chem. 278 (38): 36496–504. doi:10.1074/jbc.M306694200. PMID 12847090.
Guo Q, Xie J (2004). "AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4.". J. Biol. Chem. 279 (6): 4596–603. doi:10.1074/jbc.M309811200. PMID 14627703.
Barbato C, Corbi N, Canu N, et al. (2004). "Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis.". Mol. Cell. Neurosci. 24 (4): 1038–50. PMID 14697667.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Burgdorf S, Leister P, Scheidtmann KH (2004). "TSG101 interacts with apoptosis-antagonizing transcription factor and enhances androgen receptor-mediated transcription by promoting its monoubiquitination.". J. Biol. Chem. 279 (17): 17524–34. doi:10.1074/jbc.M313703200. PMID 14761944.
Xie J, Guo Q (2004). "AATF protects neural cells against oxidative damage induced by amyloid beta-peptide.". Neurobiol. Dis. 16 (1): 150–7. doi:10.1016/j.nbd.2004.02.003. PMID 15207272.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220.
Kaul D, Mehrotra A (2007). "Functional characterization of AATF transcriptome in human leukemic cells.". Mol. Cell. Biochem. 297 (1-2): 215–20. doi:10.1007/s11010-006-9317-1. PMID 17006618.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

External links

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